Latin music fans from coast to coast and around the world enjoyed an event filled with unforgettable moments and spectacular music, which began with an outstanding joint performance by Aventura, Wisin & Yandel, and Akon, which was immediately followed by Jenni Rivera. Top honors at the most important and prestigious Latin music event went to Flex who received eight Billboard Latin Music Awards, and performed his mega hit "Te Quiero;" while Enrique Iglesias was honored with six Awards, and surprised audiences with a live broadcast from Minsk, Belaruse. Aventura and Mana, received four awards each.

Billboard's special recognitions went to multi-platinum selling artist, Carlos Santana, who received the Billboard Lifetime Achievement Award for his outstanding music career and Reggaeton star Daddy Yankee, was honored with the Billboard Spirit of Hope Award for his commitment and humanitarian work through his foundation "Corazon Guerrero" (Heart of Warrior). Santana surprised the audience, when he joined Mana in a memorable performance. Daddy Yankee also performed an energetic number joined by the all-male dance troupe Jabbawockeez.

Artists who received two Billboard Latin Music Awards included, Ivy Queen, Jenni Rivera and Vicente Fernandez. Those honored with one award were, Armando Avila, Gilberto Santa Rosa, Gloria Trevi, Isidro Chavez, K-Paz de la Sierra, Los Dareyes de la Sierra, Los Temerarios, Marco Antonio Solis, Pitbull, RBD and Wisin & Yandel.